Chemically Precise Glycoengineering Improves Human Insulin
نویسندگان
چکیده
منابع مشابه
Semisynthesis of Human Insulin Utilizing Chemically Modified Carboxypeptidase
It has previously been demonstrated that the C-terminal alanyl residue in the B-chain of porcine insulin can be exchanged with a threonyl residue in a carboxypeptidase Y catalyzed transpeptidation reaction using threonine amide as nucleophile. However, with this procedure the transpeptidation product, human insulin amide, was obtained in relatively low yields. In the present paper it is demonst...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2017
ISSN: 1554-8929,1554-8937
DOI: 10.1021/acschembio.7b00794